What is the KLOW Stack?
Short answer
The KLOW Stack is a compounded blend of four peptides in one vial: BPC-157, GHK-Cu, KPV and TB-500. It adds KPV, a three-amino-acid fragment of alpha-MSH studied in animal and cell models of intestinal inflammation, to the Glow Stack. No trial of the combination has been published. It is prescription-only, not FDA-approved, and contains two WADA-prohibited compounds.
| Type | Four-peptide blend in one vial |
|---|---|
| Components | BPC-157, GHK-Cu, KPV (Lys-Pro-Val fragment of alpha-MSH), TB-500 |
| Also known as | KLOW blend, BPC-157 / GHK-Cu / KPV / TB-500 blend |
| Evidence to date | Animal, in vitro and review literature per compound; KPV data is animal and cell models; no trials of the combination |
| Form in this catalog | Subcutaneous injection, supplied already reconstituted |
| Regulatory status | Compounded medication; not FDA-approved for any use |
| Anti-doping | BPC-157 and TB-500 prohibited at all times (WADA); GHK-Cu and KPV not named on the list |
| Study type | Sources |
|---|---|
| Human clinical trials | 0 |
| Other human studies | 0 |
| Animal and lab studies | 1 |
| Review articles | 4 |
What is in the KLOW Stack?
The KLOW Stack is four peptides in one vial: BPC-157, GHK-Cu, KPV and TB-500. It is the widest stack in this catalog, the Glow Stack's three compounds plus KPV. BPC-157 is a 15-amino-acid fragment of a protective protein from human gastric juice, TB-500 is a 17-amino-acid fragment of thymosin beta-4 covering its actin-binding region, and GHK-Cu is a copper-binding tripeptide found naturally in human plasma.
KPV is the compound that sets this stack apart. It is the three-amino-acid C-terminal fragment, lysine-proline-valine, of alpha-melanocyte-stimulating hormone, a hormone involved in pigmentation and in inflammatory signaling. KPV has been studied on its own in animal and cell models of intestinal inflammation, which is why the KLOW Stack is described as spanning gut, skin and soft tissue.
What has the KLOW Stack been studied for?
The KLOW Stack as a four-compound combination has no published trial, and no study has examined any three of its components together either. BPC-157 reviews describe animal models of wound, tendon, muscle and gut repair, including fistulas. TB-500 and its parent thymosin beta-4 have animal data on cell migration and tissue repair. GHK-Cu reviews describe regenerative actions in cell and animal studies, with its human evidence mostly topical and cosmetic.
KPV has the narrowest literature of the four. The animal and cell study in the references examined how the tripeptide is taken up through an intestinal transporter called PepT1 and reported reduced intestinal inflammation in those models. A review of alpha-MSH and its related tripeptides summarizes anti-inflammatory and protective effects in vitro and in vivo and frames the future of the field in terms of immune-mediated inflammatory disease. None of that is a human trial of KPV, and none of it concerns injecting it alongside three other peptides.
| Compound | Type of evidence | What the reviews describe |
|---|---|---|
| BPC-157 | Animal models, reviews | Wound, tendon, muscle, gut and fistula repair models |
| GHK-Cu (injectable) | In vitro and animal studies, reviews | Skin and connective-tissue remodeling pathways |
| KPV | Animal and cell study, one review | Intestinal inflammation models; PepT1 uptake; alpha-MSH family signaling |
| TB-500 | Animal and cell studies, one review | Cell migration and tissue repair models |
| The combination | No published trials | Nothing |
Get KLOW Stack prescribed, pre-mixed
How is the KLOW Stack prescribed?
The KLOW Stack is prescribed in the US as a compounded medication: a licensed provider reviews an individual's intake and history, and a licensed 503A pharmacy prepares the four-peptide blend. Through Peptides.build it is prescribed as a subcutaneous injection and arrives already reconstituted, with each peptide's concentration on the pharmacy label, so no reconstitution happens at home.
Breadth is the reason to consider it and the reason to hesitate. Four compounds in one liquid means four fixed ratios that cannot be adjusted separately and four sets of history for a provider to weigh. BPC-157 and GHK-Cu are each available on their own, and the narrower Wolverine and Glow stacks exist, so most intake conversations start with fewer compounds and let the provider decide whether a wider stack is justified. Dosing is set by the provider and is never published here.
Is the KLOW Stack FDA-approved or allowed in sport?
The KLOW Stack is not FDA-approved for any use. None of BPC-157, GHK-Cu, KPV or TB-500 is FDA-approved for any use, and the blend is a compounded medication; compounded medications are not FDA-approved.
In sport, two of its four compounds, BPC-157 and TB-500, are prohibited at all times by the World Anti-Doping Agency as non-approved substances. GHK-Cu and KPV are not named on the list, but the list's S0 category can cover non-approved substances, and a blend cannot be taken in part. Drug-tested athletes should treat the stack as prohibited and check with their governing body.
How are KLOW Stack doses measured?
KLOW Stack doses are drawn from a single vial whose label lists a concentration for each of the four peptides, and every unit on a U-100 insulin syringe carries all four at the label's ratio. There is no four-compound calculator on this site, and the single-compound calculators for BPC-157 and GHK-Cu are only a way to check the arithmetic on one component at a time. The provider states how many units to draw, and that instruction, not a tool, is what patients follow.
Prescribed KLOW Stack (BPC-157 / GHK-Cu / KPV / TB-500) vs research peptides: what is different?
Prescribed KLOW Stack (BPC-157 / GHK-Cu / KPV / TB-500) is not a research chemical. It is a prescription medication: a licensed US provider reviews your intake first, and a licensed 503A pharmacy compounds it for you by name. Vials sold online as “research use only” skip both steps. What you pay for here is that review, a pharmacy you can name, and a label that says what is in the vial.
A research seller’s certificate of analysis is a document the seller controls: it chooses the lab and the sample, and a PDF can be reused, edited or re-dated. No regulator checks it.
| Point | Prescribed through Peptides.build | Research use only |
|---|---|---|
| Access | Online intake reviewed by a licensed US provider; prescribed only when appropriate. | No prescription and no clinical review of whether it suits you. |
| How it's labeled | A prescription medication compounded for you by name. | Commonly sold labeled “research use only, not for human consumption.” |
| Who prepares it | A licensed 503A US compounding pharmacy under state and federal oversight. | Unregulated suppliers, often with no verifiable chain of custody. |
| Testing | Third-party tested. | Certificates of analysis are self-reported when provided at all. |
| Purity and identity | Prepared to a prescription for a specific patient. | Purity, strength, and even identity are unverified by any independent party. |
This compares two care models, not two products. Compounded medications are not FDA-approved, and we do not claim otherwise. What a prescription adds is a licensed provider deciding whether a protocol is appropriate for you and a licensed pharmacy preparing it. Read the full guide to research vs prescription peptides.
KLOW Stack (BPC-157 / GHK-Cu / KPV / TB-500) FAQ
What does KPV add to the KLOW Stack?
KPV is the lysine-proline-valine fragment of alpha-MSH, studied in animal and cell models of intestinal inflammation. It is the component that gives the KLOW Stack its gut angle; the other three compounds are the Glow Stack.
What is the difference between the KLOW Stack and the Glow Stack?
One peptide. The Glow Stack is BPC-157, GHK-Cu and TB-500; the KLOW Stack is those three plus KPV in the same vial. Whether the extra compound is justified is a provider decision.
Has the KLOW Stack been tested in humans?
No. No published trial has examined the four-compound combination, and KPV itself has animal and cell data only. The other components have animal, in vitro and review literature, and GHK-Cu's human data is mostly topical cosmetic studies.
Is the KLOW Stack FDA-approved?
No. It is a compounded medication, and compounded medications are not FDA-approved; none of its four compounds is FDA-approved for any use. It is prescribed only by a licensed provider for an individual patient.
Is the KLOW Stack banned in sport?
It contains BPC-157 and TB-500, both prohibited at all times by the World Anti-Doping Agency, so drug-tested athletes should treat the whole blend as prohibited. GHK-Cu and KPV are not named on the list. Check with your governing body.
KLOW Stack through Peptides.build
A licensed US provider reviews a short online intake and decides whether a protocol is appropriate. A US 503A pharmacy prepares it already reconstituted, labels the concentration and ships it cold-chain. Dosing is set by the provider and is not published on this site.
Start your KLOW Stack visit · from $183/moReferences
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 2008. doi:10.1053/j.gastro.2007.10.026Study type: Animal and cell study
- Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocrine Reviews, 2008. doi:10.1210/er.2007-0027Study type: Review
- Fistulas Healing: Stable Gastric Pentadecapeptide BPC 157 Therapy. Current Pharmaceutical Design, 2020. doi:10.2174/1381612826666200424180139Study type: Review
- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences, 2018. doi:10.3390/ijms19071987Study type: Review
- Thymosin beta4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 2012. doi:10.1517/14712598.2012.634793Study type: Review
Citations are listed with their study type so the evidence can be weighed. Review articles summarize other studies; animal and in vitro findings do not describe outcomes in people.
This article is educational and is not medical advice. KLOW Stack (BPC-157 / GHK-Cu / KPV / TB-500) is not FDA-approved for any use, and compounded medications are not FDA-approved. No results are implied or guaranteed. Talk to a licensed provider about your own history before starting any protocol.