What is DSIP?
Short answer
DSIP, delta sleep-inducing peptide, is a nine-amino-acid peptide first isolated from rabbit cerebral venous blood in 1970s sleep research. Reviews from 1984 and 1986 summarize human and animal findings that are mixed, and it is not a sedative. In the US it is available only as a compounded medication prescribed by a licensed provider; compounded medications are not FDA-approved, and DSIP is not FDA-approved for any use. It is not named on the WADA list.
| Type | Nonapeptide (9 amino acids); a naturally occurring sequence produced synthetically |
|---|---|
| Origin | Isolated from rabbit cerebral venous blood in 1970s sleep research |
| Also known as | Delta sleep-inducing peptide, DSIP peptide |
| Evidence to date | Human and animal studies from the 1970s and 1980s, summarized in reviews; findings are mixed |
| Form in this catalog | Subcutaneous injection, supplied already reconstituted |
| Regulatory status | Compounded medication; not FDA-approved for any use |
| Anti-doping | Not named on the WADA Prohibited List; the S0 non-approved substances category can apply |
| Study type | Sources |
|---|---|
| Human clinical trials | 0 |
| Other human studies | 0 |
| Animal and lab studies | 0 |
| Review articles | 2 |
Where does DSIP come from?
DSIP is a nonapeptide, nine amino acids long, that was first isolated in the 1970s from the cerebral venous blood of rabbits during experiments on sleep. The name, delta sleep-inducing peptide, refers to the delta-wave stage of sleep those experiments were tracking, and it was given before anyone knew how the peptide behaved in people. The name has outlived the certainty behind it.
DSIP as prescribed is synthetic: a compounding pharmacy assembles the nine-residue sequence rather than extracting it from tissue. It belongs to an older generation of peptide research than most of this catalog, which is why its key citations are review articles from 1984 and 1986 rather than recent trials, and why anyone quoting a confident modern result for it should be asked where it came from.
What has DSIP been studied for?
DSIP research peaked in the decade after its discovery, and the two reviews cited here, from 1984 in Neuroscience and Biobehavioral Reviews and from 1986 in Peptides, summarize that period. They cover work in both animals and humans on sleep architecture, the structure of sleep stages across a night, and on a range of other physiological measures that researchers tested once the peptide was available. The honest word for the findings is mixed: some studies reported changes in sleep measures and others did not.
DSIP is not a sedative, and nothing in the review literature describes it as a hypnotic drug in the way sleeping pills are. It is a signaling peptide that was studied in relation to sleep stages, and the research does not support positioning it for insomnia or any sleep disorder. If disrupted sleep is affecting your life, that is a clinician conversation first; a protocol is a provider decision made after it, not instead of it.
| Area | Type of evidence | What the reviews describe |
|---|---|---|
| Sleep architecture | Human and animal studies, 1970s and 1980s, summarized in reviews | Mixed findings on sleep-stage measures |
| Other physiological measures | Animal and small human studies | Exploratory findings, summarized rather than confirmed |
| Mechanism | Review discussion | Described as a signaling peptide; mechanism not settled |
| Humans, recent | No recent controlled trials among the studies cited here | The evidence rests on the older literature |
Get DSIP prescribed, pre-mixed
How is DSIP prescribed?
DSIP is prescribed in the US as a compounded medication: a licensed provider reviews an online intake, writes a prescription for one patient, and a licensed 503A pharmacy prepares it. Through Peptides.build it is a single-compound protocol, prescribed as a subcutaneous injection that ships already reconstituted with the concentration on the pharmacy label. It is not part of any stack in this catalog.
DSIP sits in the Cognitive goal on this site alongside the Semax / Selank protocol and MOTS-c, the protocols that address the part of performance that happens away from training. The provider decides whether it fits your history and sets the protocol; dosing is never published on this site.
Is DSIP FDA-approved or allowed in sport?
DSIP is not FDA-approved for any use, and there is no approved DSIP product in the US. The compounded form is prepared by a 503A pharmacy for a specific patient, and compounded medications are not FDA-approved.
DSIP is not named on the World Anti-Doping Agency Prohibited List. The list's S0 category can cover non-approved substances, so drug-tested athletes should check with their governing body rather than treat the absence of a name as permission.
How are DSIP doses measured?
DSIP prescriptions are written in micrograms, and the doses are small relative to the vial, which is why pharmacy labels for DSIP are often written at lower concentrations than for other peptides: a dilute vial makes a small draw easier to read on a syringe. The label may state the strength in mcg/mL or mg/mL. The free DSIP calculator on this site converts a prescribed dose and a label strength into units on a U-100 insulin syringe; it performs arithmetic only and does not recommend a dose.
Prescribed DSIP vs research peptides: what is different?
Prescribed DSIP is not a research chemical. It is a prescription medication: a licensed US provider reviews your intake first, and a licensed 503A pharmacy compounds it for you by name. Vials sold online as “research use only” skip both steps. What you pay for here is that review, a pharmacy you can name, and a label that says what is in the vial.
A research seller’s certificate of analysis is a document the seller controls: it chooses the lab and the sample, and a PDF can be reused, edited or re-dated. No regulator checks it.
| Point | Prescribed through Peptides.build | Research use only |
|---|---|---|
| Access | Online intake reviewed by a licensed US provider; prescribed only when appropriate. | No prescription and no clinical review of whether it suits you. |
| How it's labeled | A prescription medication compounded for you by name. | Commonly sold labeled “research use only, not for human consumption.” |
| Who prepares it | A licensed 503A US compounding pharmacy under state and federal oversight. | Unregulated suppliers, often with no verifiable chain of custody. |
| Testing | Third-party tested. | Certificates of analysis are self-reported when provided at all. |
| Purity and identity | Prepared to a prescription for a specific patient. | Purity, strength, and even identity are unverified by any independent party. |
This compares two care models, not two products. Compounded medications are not FDA-approved, and we do not claim otherwise. What a prescription adds is a licensed provider deciding whether a protocol is appropriate for you and a licensed pharmacy preparing it. Read the full guide to research vs prescription peptides.
DSIP FAQ
Is DSIP a sleeping pill?
No. DSIP is a signaling peptide studied in relation to sleep stages, not a sedative or a hypnotic. It is not prescribed through this site as a treatment for insomnia or any sleep disorder.
What does the research on DSIP show?
The research is from the 1970s and 1980s, summarized in reviews from 1984 and 1986, and the findings are mixed: some studies reported changes in sleep measures and others did not. No recent controlled trial is among the studies cited here for this site.
Is DSIP natural?
The DSIP sequence was isolated from rabbit blood, so it is a naturally occurring peptide, but the prescribed form is synthetic, assembled by a compounding pharmacy. Natural origin does not change its regulatory status.
Is DSIP FDA-approved?
No. DSIP is not FDA-approved for any use. In the US it is available only as a compounded medication prescribed by a licensed provider and prepared by a licensed 503A pharmacy; compounded medications are not FDA-approved.
Is DSIP banned in sport?
DSIP is not named on the WADA Prohibited List. The S0 category for non-approved substances can apply, so drug-tested athletes should check with their governing body before using it.
Does DSIP need to be reconstituted?
Not through this site: DSIP prescribed through Peptides.build ships already reconstituted, with the concentration on the pharmacy label. The DSIP calculator covers reading that label; it also handles powder vials, but patients here do not add water.
DSIP through Peptides.build
A licensed US provider reviews a short online intake and decides whether a protocol is appropriate. A US 503A pharmacy prepares it already reconstituted, labels the concentration and ships it cold-chain. Dosing is set by the provider and is not published on this site.
Start your DSIP visit · from $158/moReferences
- Delta-sleep-inducing peptide (DSIP): a review. Neuroscience and Biobehavioral Reviews, 1984. doi:10.1016/0149-7634(84)90022-8Study type: Review
- Delta-sleep-inducing peptide (DSIP): an update. Peptides, 1986. doi:10.1016/0196-9781(86)90148-8Study type: Review
Citations are listed with their study type so the evidence can be weighed. Review articles summarize other studies; animal and in vitro findings do not describe outcomes in people.
This article is educational and is not medical advice. DSIP is not FDA-approved for any use, and compounded medications are not FDA-approved. No results are implied or guaranteed. Talk to a licensed provider about your own history before starting any protocol.